177 Lu‐PSMA‐617 offers a potential additional life‐prolonging treatment option for men with mCRPC. The results of this trial will determine, for the first time in a randomized design, the activity and safety of 177 Lu‐PSMA‐617, as compared with cabazitaxel chemotherapy in men with progressive mCRPC.

Lutetium PSMA therapy, or 177 Lu-PSMA therapy, is a treatment for advanced prostate cancer which has metastasized to other parts of the body. It is currently in clinical trials. Prostate-specific membrane antigen

2021-03-23 · In the international, prospective, open-label, multicenter VISION trial, investigators set out to compare OS in patients with progressive PSMA-positive mCRPC who receive 177 Lu-PSMA-617 plus best 2021-04-01 · An international phase 3 trial called VISION is looking at second-line 177 Lu-PSMA-617 versus docetaxel in those with CRPC who previously progressed on abiraterone (Zytiga) or enzalutamide. Azad says that 177 Lu-PSMA-617 has shown efficacy in metastatic CRPC in late-stage disease, and there are more data coming out in that area. 2020-08-26 · In 2018, Endocyte/Novartis started a phase 3 trial, known as the VISION-trial (NCT03511664), to prospectively study the efficacy and toxicity profile of [177 Lu]Lu-PSMA-617 therapy. Four Dutch hospitals participated in this study, in which 750 metastatic PCa patients were randomly (2:1) assigned to two study-arms: either treatment with 7.4 GBq [ 177 Lu]Lu-PSMA-617 per cycle or best supportive care.

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Study of 177Lu-PSMA-617 In Metastatic Castrate-Resistant Prostate Cancer (VISION) The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. VISION: An international, prospective, open-label, multicenter, randomized phase III study of 177Lu-PSMA-617 in the treatment of patients with progressive PSMA-positive metastatic castration-resistant prostate cancer (mCRPC). VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of 177Lu-PSMA-617 (7.4 GBq administered by i.v. infusion every 6 weeks for a maximum of 6 cycles) plus investigator-chosen best standard of care in the investigational arm, versus best standard of care in the control arm17.

I fokus för avtalet står läkemedlet Lu-PSMA-617 som till skillnad från Endocytes tidigare behandlingsfokus är utformat för att leverera en 

Lutetium-177 [177 Lu]-PSMA-617 (LuPSMA), is a small molecule inhibitor that binds with high affinity to prostate-specific membrane antigen (PSMA). The short-range 1 mm path length of the beta-particle emitted by 177 Lu enables effective delivery of radiation to tumours while minimising damage to surrounding normal tissues.

177 Lu‐PSMA‐617 offers a potential additional life‐prolonging treatment option for men with mCRPC. The results of this trial will determine, for the first time in a randomized design, the activity and safety of 177 Lu‐PSMA‐617, as compared with cabazitaxel chemotherapy in men with progressive mCRPC.

As of Tuesday, the VISION trial  Jun 16, 2020 I'll give a little bit of note to another trial with lutetium-177 PSMA 617, and that would be the VISION trial, which is powered for overall survival,  Mar 24, 2021 Novartis phase III VISION study of 177Lu-PSMA-617 to treat metastatic castration -resistant prostate cancer meets primary endpoints. Sep 9, 2019 At the time of writing, a major multicenter, multinational Phase III trial 'VISION' is ongoing. Efficacy of 177Lu-PSMA RLT. In recent years, a  En randomiserad fas III studie pågår ”VISION”.

VISION: An international, prospective, open-label, multicenter, randomized phase 3 study of 177 Lu-PSMA-617 in the treatment of patients with progressive PSMA … VISION: An International, Prospective, Open Label, Multicenter, Randomized Phase 3 Study of 177Lu-PSMA-617 in the Treatment of Patients With Progressive PSMA-positive Metastatic Castration-resistant Prostate Cancer (mCRPC) Actual Study Start Date : May 23, 2018: Actual Primary Completion Date : January 27, 2021: Estimated Study Completion Date : 2021-03-23 VISION: An international, prospective, open-label, multicenter, randomized phase 3 study of 177 Lu-PSMA-617 in the treatment of patients with progressive PSMA-positive metastatic castration 2021-03-23 2021-03-23 2021-03-23 2019-11-01 2018-10-25 Our data provide strong evidence that [177 Lu]Lu-PSMA-617 is more active than cabazitaxel, but longer follow-up of TheraP, and results from VISION, are needed to understand the effects on overall survival. VISION (NCT03511664) is a phase 3 study designed to assess the efficacy of 177 Lu-PSMA-617 in patients with PSMA-positive mCRPC.
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The scans I had on Monday January 6, 2020 show no cancer in my bones, lymph nodes or lungs. PSA has been undetectable since June. 2020-09-14 · 177 Lu-PSMA I&T is injected intravenously and targets PSMA expressing tumors selectively. This trial will investigate if 177 Lu-PSMA-I&T RLT is an effective treatment in oHSPC, and is currently the first study investigating 177 Lu-PSMA-I&T in ADT-naïve setting, but also the first randomized prospective study with PSMA-I&T world-wide.

About VISION VISION is an international, prospective, randomized, open-label, multicenter, phase III study to assess the efficacy and safety of 177 Lu-PSMA-617 (7.4 GBq administered by i.v This edition of the ESMO 2020 Vision gives an update of what has been achieved in the first two years and outlines the tangible ESMO actions that will be implemented in the years to come, up to 2020.
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PSMA-PET-skanningar har visat mycket hög känslighet och precision vid fas 3-studie (VISION) där patienter i en lotteriförsök får antingen 177-Lu-PSMA eller 

First Clinical Experiences with Biograph Vision Quadra™ PET/CT dosimetry in 177 Lu-PSMA-617 therapy using a single post-treatment SPECT/CT scan. En nollvision för barncancer. 11.

2019-05-24

Lutetium-177 [177 Lu]-PSMA-617 (LuPSMA), is a small molecule inhibitor that binds with high affinity to prostate-specific membrane antigen (PSMA). The short-range 1 mm path length of the beta-particle emitted by 177 Lu enables effective delivery of radiation to tumours while minimising damage to surrounding normal tissues. 2 dagar sedan · There is currently only one phase 3 trial assessing 177-Lutetium-PSMA targeted therapy. This is the VISION trial, assessing the role of this radionuclide in metastatic castrate-resistant prostate cancer (mCRPC) patients (Figure 5).

2021-04-01 2020-02-16 2021-03-23 2 days ago 2021-03-23 2019-05-24 2021-03-23 2021-03-23 2020-08-26 2021-03-30 Despite the promising preliminary results of 177 Lu-PSMA-RLT, the efficacy results of VISION need to be awaited prior to using the therapy outside of compassionate use provisions. Urologe A . 2020 Jun;59(6):680-686. doi: 10.1007/s00120-020-01205-w. 177 Lu-PSMA-617 has been introduced before in this column as a PSMA-targeted radioligand therapy. 1 A Phase II Australian trial treated 30 men with metastatic castration-resistant prostate cancer who had variable lines of exposure to agents such as abiraterone, enzalutamide, docetaxel and/or cabazitaxel. 2 Seventeen (57%) patients achieved a prostate-specific antigen (PSA) decline ≥50%.